TRIM22 activates NF-κB signaling in glioblastoma by accelerating the degradation of IκBα
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چکیده
منابع مشابه
Structure of an IκBα/NF-κB Complex
Each of the IkB proteins contains six or more 33The inhibitory protein, IkBa, sequesters the transcripresidue-long ankyrin repeats, named for their homology tion factor, NF-kB, as an inactive complex in the cytoto repeats in the erythrocyte protein ankyrin (reviewed plasm. The structure of the IkBa ankyrin repeat domain, in Bork, 1993). Ankyrin, which has 24 such repeats, links bound to a parti...
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The transcription factor NF-κB is used in many systems for the transduction of extracellular signals into the expression of signal-responsive genes. Published structural data explain the activation of NF-κB through degradation of its dedicated inhibitor IκBα, but the mechanism by which NF-κB-mediated signaling is turned off by its removal from the DNA in the presence of newly synthesized IκBα (...
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main of approximately 100 amino acids in length. All IkBa regulates the transcription factor NF-kB through dimerization contacts are mediated through this second the formation of stable IkBa/NF-kB complexes. Prior domain, referred to as the dimerization domain. The to induction, IkBa retains NF-kB in the cytoplasm until carboxy-terminal 13 amino acids (NLS polypeptide), the the NF-kB activation...
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NF-κB is a ubiquitously expressed transcription factor that regulates a large number of genes in response to diverse physiological and pathological stimuli. The regulation of the transcriptional activity of NF-κB is often dependent on its interaction with IκBα. Proteins that bind to IκBα are critical regulators of NF-κB activity. DDRGK1 is a member of the DDRGK domain-containing protein family ...
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The NF-κB pathway is regulated by multiple post-translational modifications including phosphorylation, ubiquitylation and SUMOylation. Many of these modifications act on the natural inhibitor IκBα modulating its capacity to control signal-mediated NF-κB activity. While the canonical pathway involving the phosphorylation and polyubiquitylation of IκBα has been well characterized, the role of the...
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ژورنال
عنوان ژورنال: Cell Death & Differentiation
سال: 2020
ISSN: 1350-9047,1476-5403
DOI: 10.1038/s41418-020-00606-w